HORDB

ID: hor005755
Uniprot ID: O76818
Protein name: Gamma-SG neuropeptide
Gene name: NA
Organism: Agrotis ipsilon (Black cutworm moth)
Family: Pyrokinin family
Source: animal
Expression: Pheromone biosynthesis-activating neuropeptide: Expressed in the mandibular, maxillary and labial neuromeres of the male and female brain-subesophageal ganglions, in the corpora cardiaca and all around the corpora allata, and at a lower level in the brain
Disease: NA
Comments: NA
Taxonomy: Agrotis (genus), Noctuini (tribe), Noctuinae (subfamily), Noctuidae (family), Noctuoidea (superfamily), Obtectomera , Ditrysia , Heteroneura (parvorder), Neolepidoptera (infraorder), Glossata (suborder), Lepidoptera (order), Amphiesmenoptera (superorder), Endopterygota (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia , Insecta (class), Hexapoda (subphylum), Pancrustacea , Mandibulata , Arthropoda (phylum), Panarthropoda , Ecdysozoa , Protostomia , Bilateria , Eumetazoa , Metazoa (kingdom), Opisthokonta , Eukaryota (superkingdom),cellular organisms
GO MF: GO:0005179 hormone activity; GO:0005184 neuropeptide hormone activity
GO BP: GO:0007218 neuropeptide signaling pathway; GO:0019236 response to pheromone; GO:0042811 pheromone biosynthetic process
GO CC: GO:0005576 extracellular region

Sequence: TMNFSPRL
Length: 8(161-168)
Propeptide: MYGAVLPGLFFIFISCVVASSNDVKDGGADRGAHSDRGGMWFGPRIGKRSLRMATEDNRQAFFKLLEAADALKYYYDQLPYEMQADEPEARVTKKVIFTPKLGRSLSYEDKMFDNVEFTPRLGRRLADDTPATPADQEMYRPDPEQIDSRTKYFSPRLGRTMNFSPRLGRELAYEMLPSKVRVVRSTNKTQST
Signal peptide: MYGAVLPGLFFIFISCVVA
Modification: T8 Leucine amide
Glycosylation: NA
Mutagenesis: NA

Function: [Pheromone biosynthesis-activating neuropeptide]: A hormone that controls sex pheromone production in female moths and pheromone responsiveness in male (PubMed:9753769).
Mechanism: Juvenile hormone seems to allow PBAN release, which then induces pheromone biosynthesis.
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor005755_AF2.pdb

hor005755_ESM.pdb

Mass:	109016	Formula:	C42H68N12O12S
Absent amino acids:	ACDEGHIKQVWY	Common amino acids:	FLMNPRST
pI:	10.55	Basic residues:	1
Polar residues:	3	Hydrophobic residues:	2
Hydrophobicity:	-32.5	Boman Index:	-1728
Half-Life:	7.2 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	48.75
Instability Index:	3546.25	Extinction Coefficient cystines:	0
Absorbance 280nm:	0

PubMed ID: 9753769
Title: The pheromone biosynthesis activating neuropeptide (PBAN) of the black cutworm moth, Agrotis ipsilon: immunohistochemistry, molecular characterization and bioassay of its peptide sequence.
PubMed ID: 29466015
Title: Mating-Induced Differential Peptidomics of Neuropeptides and Prot